Maryland University (USA) : David Bennett, the first person to receive a heart transplant from a gene-edited pig, two months ago died.
After the groundbreaking experiment, the hospital that performed the surgery to
57-year-old Bennett announced his death on Tuesday. A hospital in Maryland in the United States, and doctors did give an exact cause of death.
In a statement on Wednesday the hospital said his condition began deteriorating several days ago, adding that Bennett was given “compassionate palliative care” after it became clear that he would not recover.
Over decades doctors had sought to one day use animal organs for life-saving transplants for human being. Bennett, a handyman from Hagerstown, Maryland, was a candidate for this newest attempt only because he otherwise faced certain death — ineligible for a human heart transplant, bedridden and on life support, and out of other options.
Prior attempts at such transplants – or xenotransplantation – have failed largely because patients’ bodies rapidly rejected the animal organ. This time, the Maryland surgeons used a heart from a gene-edited pig. Scientists had modified the animal to remove pig genes that trigger the hyper-fast rejection and add human genes to help the body accept the organ.
Bennett’s son praised the hospital for offering the last-ditch experiment, saying the family hoped it would help further efforts to end the organ shortage. “We hope this story can be the beginning of new hope and not the end.”
After last January 7 operation, the pig heart was functioning, and the Maryland hospital issued periodic updates that Bennett seemed to be slowly recovering. Last month, the hospital released video of him watching the Super Bowl from his hospital bed while working with his physical therapist.
Bennett survived significantly longer with the gene-edited pig heart than in one of the last milestones in xenotransplantation – when Baby Fae, a dying California infant, lived 21 days with a baboon’s heart in 1984.
The need for another source of organs is huge. More than 41,000 transplants were performed in the US last year, a record – including about 3,800 heart transplants. But more than 106,000 people remain on the national waiting list, thousands die every year before getting an organ and thousands more never even get added to the list, considered too much of a long shot.
But from Bennett’s experience, “we have gained invaluable insights learning that the genetically modified pig heart can function well within the human body while the immune system is adequately suppressed,” said Dr Muhammad Mohiuddin, scientific director of the Maryland university’s animal-to-human transplant programme.
